Tuesday, December 13, 2022

Stiff Person Syndrome in the Central Nervous System and the role of GABA

GABA is a inhibitory or moderator and rate limiter for signaling in the CNS. I was diagnosed about nine years ago with an idiopathic variant. My blood tested excessive in key areas illustrating my symptoms and complaints.

GABA works on the same receptors that alcohol activates to downplay or relax the noise activity and intensity of the signaling pathways. Some signaling drops before it reaches the brain or it’s too weak to register. 

Without the biochemistry to tune relaxation cycles the muscles can destroy themself slowly by losing rest. The circuit breakers (GABA) are depleted allowing an amplified reflection of pain returning from the muscles via pain signaling. It’s a double whammy. 

My deltoids will barely let me post today. Goodnight.