Stiff Person Syndrome in the Central Nervous System and the role of GABA

GABA is a inhibitory or moderator and rate limiter for signaling in the CNS. I was diagnosed about nine years ago with an idiopathic variant. My blood tested excessive in key areas illustrating my symptoms and complaints.

GABA works on the same receptors that alcohol activates to downplay or relax the noise activity and intensity of the signaling pathways. Some signaling drops before it reaches the brain or it’s too weak to register. 

Without the biochemistry to tune relaxation cycles the muscles can destroy themself slowly by losing rest. The circuit breakers (GABA) are depleted allowing an amplified reflection of pain returning from the muscles via pain signaling. It’s a double whammy. 

My deltoids will barely let me post today. Goodnight. 

Panic Attacks are part of life at times

 https://www.facebook.com/watch/?v=269569431446619

Stiff Man Syndrome can take 7.5 years to come to a diagnosis

I was in the E.R. some weeks or a month ago or so, when an interested Nurse or Doctor asked me further questions about Stiff Man Syndrome, I had a few answers. I was informed it can take 7.5 years on average to come to this diagnosis. It's also called Stiff Person Syndrome sometimes, however "person" does not translate so well in a number of languages, and the de-facto diagnosis is called "Stiff Man Syndrome" in place of "Stiff Person Syndrome".

While lower GABA has been shown in VA patients with PTSD, the chemistry is in the Generalized Anxiety Disorder neighborhood. There are a few known causes of Stiff Man Syndrome, and there is also an idiopathic form too.